Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer.

Pilot trial evaluating an 123I-labeled 80-kilodalton engineered anticarcinoembryonic antigen antibody fragment (cT84.66 minibody) in patients with colorectal cancer.

(V(L)-linker-V(H)-C(H)3
Mean serum residence time of the minibody was 29.8 h (range, 10.9-65.4 h).
All 10 patients were evaluated for immune responses to the minibody

Fcを残してADCC狙い＋低分子化（150kDa→80kDa)で組織浸潤狙い
狙いは上記2点で良いのかな。
血中滞留性を保ちながら（アルブミンにくっついて）で、だんだんはずれて、はずれたものが組織浸潤、
というわけにいったら、なんとかならないかしら。

References
Cytotoxic effects of T cells induced by fusion protein 6B11-pulsed dendritic cells on ovarian carcinoma cells 2007.4

Minibody: A Novel Engineered Anti-Carcinoembryonic Antigen Antibody Fragment (Single-Chain Fv-CH3) Which Exhibits Rapid, High-Level Targeting of Xenografts1 1996

A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor 2005